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DeepMind's AlphaFold 3 extends beyond proteins to accurately predict the structures of complexes including DNA, RNA, small molecules, ions, and modified residues. This represents a major leap in computational biology with implications for drug discovery and understanding molecular mechanisms.
Researchers report superconductivity at 294 K (21°C / 70°F) in nitrogen-doped lutetium hydride at 10 kbar pressure - the closest yet to ambient conditions. If replicated, this could revolutionize energy transmission and quantum computing.
Using large-scale neural recordings, researchers mapped how prior expectations are encoded across the entire mouse brain during perceptual decisions. The findings reveal a distributed network that updates beliefs based on experience - key to understanding how brains make predictions.
How does it brok the fundamentals?
This paper introduces a generative AI that designs efficient synthesis routes for organic molecules, potentially accelerating drug development and materials science by automating one of chemistry's most complex challenges.
It seems like it shows superposition of molecules with several atoms, that’s interesting
Google DeepMind's team has found a way to leverage ML for predictions of functional differences resulting from changes in DNA sequences.
This paper finds that deep mantle processes caused the Green River to connect to the Colorado River through the Uinta Mountains. Carved a big canyon in the process. Would be the first geology/Earth science paper you guys have done - and it's my paper and I'm a big fan!
New (ancient) form of life
I saw your post on the new tool used for measuring stomata openings. I’m a plant nerd and I think you guys would get a kick out of this newly discovered way of plants consuming nutrients via oxidation of microbes.
This paper demonstates a new source of renewable power and proposes a charging mechanism to explain triboelectric phemonena at the solid-liquid interface.
paper represents a major milestone in gene-editing and neurotherapeutics because it reports the first published demonstration of non-viral CRISPR delivery into the brain of a large animal, overcoming one of the most persistent barriers in translational neuroscience. By using a peptide-mediated delivery system to transport CRISPR enzymes directly into neurons in vivo, we not only expand the toolbox for precise gene editing beyond viral vectors—with their safety and immunogenicity limitations—but also bring the field closer to viable treatments for complex neurological disorders. This breakthrough sits at the intersection of cutting-edge technology, clinical potential, and deep ethical implications, making it an ideal topic for a wide-reaching podcast audience interested in where gene therapy is headed and how science is redefining the future of brain medicine.
Paper documents the first success of a pancreatic cancer cure in mice models using a 3 drug combination inhibition model.
CISS promises profound and ubiquitous implications for existing technologies and new approaches to answering age old questions, such as the homochiral nature of life.
By decoding the chemistry of microscopic fossils buried in ocean sediments, paleoclimate scientists can reconstruct how the oceans shaped Earth’s past climate and carbon cycle. This study uses those tools to show that changes in deep-ocean salinity helped trap carbon dioxide in the abyssal ocean during the last ice age, confirming the prevailing theory that ocean processes help govern natural CO2 variations in Earth history.
It is well documented that males and females are diagnosed with Alzheimer’s disease at different rates. But we still do not have a great understanding of why this is the case. We can only improve any possible treatment or prevention of this disease if we know the why, when, and where these differences are occurring. New research led by O’Banion and Neuroscience graduate student Lia Calcines-Rodríguez at the University of Rochester, discovered that the immune cells in the brain, known as microglia, act differently in the male and female Alzheimer’s brain, and appear to cause residual harm in the female brain.
A pilot clinical trial shows that epidural spinal cord stimulation (SCS) in spinal muscular atrophy, a neurodegenerative disease, can revert motorneuron dysfunction and improve motor function. This technology is becoming unavoidable for treatment of motor disorders and could be used with BCI
Standard economics assumes equilibrium. My paper, "The Dissipative Structure of Value," assumes only geometry. By treating market data as a continuous probability fluid, I built a computational framework (Madelung Flow Regression) that unifies Quantum Hydrodynamics, Stochastic Thermodynamics, and Information Geometry into a single mathematical object. I applied this to a decade of NYC real estate data and didn't just find correlations, I recovered the "physics" of the market. A derived "Heisenberg Limit": Markets have a hard geometric constraint where consensus kills velocity. It empirically proves Georges Bataille’s 1949 theory of the "Accursed Share", showing that the market functions as an expenditure engine (dissipating surplus) 81% of the time, rather than an allocation engine. The Future: This framework offers a blueprint for "Madelung Flow Denoising", marrying diffusion models with geometric inversion to create AI that outputs interpretable physical laws instead of black-box correlations. It is a new approach to Causal World Modeling. A Universal Dynamical Systems Microscope effectively.
This new drug is now in human trials and could see widespread use this decade. Would love to understand the differences between teath and regular bone as it pertains to regrowth.
This paper is pretty recent (december 17th) shows a new way to boost aging immune systems. The researchers deliver mRNA to the liver so it briefly produces a small set of proteins that the body normally uses to build and maintain immune cells, specifically T cells. In old mice, this restored key immune function, leading to stronger vaccine responses and better anti-tumor immunity. Big picture, it demonstrates a “programmable medicine” approach where the liver can act like a temporary drug factory (kinda like the iDegs paper), releasing precisely tuned immune signals. This has potential to reduce risk of immunotherapies like vaccines inducing some sort of chronic or unlocalized inflammation response (with caveats).
I saw a post about mosquito proboscides being used as 3d printer nozzles, definitely something wild to cover! Note: The category dropdown doesn't seem to have any options besides "Other", not sure if you're currently aware of that.
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